Table 2.
Responders in subgroups after 12-week treatment (intention to treat analysis, chi- square test, last observation carried forward (LOCF))
| Definition of subgroups | Rate of responder | ||
|---|---|---|---|
| EcN group [%] | Placebo group [%] | p-value (one sided) | |
| Gastroenteritis and/or antibiotics prior to onset of symptoms | 60.0 | 14.3 | 0.0297 |
| Constipation predominanta | 57.9 | 50.0 | 0.3202 |
| Diarrhea predominanta | 51.9 | 51.9 | 0.5000 |
| Alternating stool habitsa | 61.8 | 48.6 | 0.1336 |
| Abdominal paina | 54.8 | 50.0 | 0.3482 |
| Meteorisma | 58.0 | 48.2 | 0.1568 |
| Flatulencea | 54.9 | 44.2 | 0.1394 |
| Urgencya | 55.6 | 50.0 | 0.3208 |
| Nauseaa | 63.2 | 50.0 | 0.2249 |
EcN Escherichia coli Nissle 1917
aPresent at inclusion into the study