Table 2.

Correlation between anastomotic leakage and clinicopathological factors in patients who underwent simultaneous resection for SCLM

		Leakage (−) (n = 63)	Leakage (+) (n = 18)	Univariate analysis p value	Multivariate analysis p value, RR (95%CI)
Patient characteristics
Median age (range) (years)		59 (40–85)	59 (41–73)	0.81
Male/female		33/30	12/6	0.42
BMI (mean ± SD)		21.9 ± 2.9	22.5 ± 2.2	0.44
Preoperative comorbidity
Absent		44	12	0.78
Present		19	6
Primary colorectal tumor
Site	Colon	42	6	0.01	N.S.
	Rectum	21	12
Stenosis	Absent	56	0	0.34
	Present	7	18
Tumor size, mm		52.0	58.0	0.25
pT stage	pT3	41	9	0.25
	pT4	22	9
pN stage	pN0	17	2	0.22
	pN+	46	16
Histology	Well, mod	60	15	0.12
	Poor	3	3
Liver metastasis
Distribution	Unilobar	38	9	0.43
	Bilobar	25	9
Number of tumors (range)		2.3 (1–8)	2.6 (1–8)	0.57
Tumor size, mm		47	33	0.06
Operative factors
Lateral lymph node dissection
Absent		55	10	<0.01	N.S.
Present		8	8
Diverting stoma
Absent		48	11	0.24
Present		15	7
Liver resection
Partial Hx, segmentectomy		51	16	0.72
≥Lobectomy		12	2
Timing of anastomosis
Colectomy → anastomosis → Hx		20	4	0.20
Colectomy → Hx → anastomosis		7	5
Hx → colectomy → anastomosis		36	9
Pringle maneuver
Absent		10	1	0.44
Present		53	17
Operation time
<8 h		53	8	<0.01	<0.01, 6.63 (2.09–20.9)
≥8 h		10	10
Blood loss, g (range)		1,345 (162–6,000)	2,487 (430–6,560)	0.02	N.S.
Transfusion
Absent		39	9	0.37
Present		24	9
Blood transfusion, ml		343	1,212	0.05

RR relative risk, CI confidence interval, Hx hepatectomy, N.S. non-significant (p > 0.05)