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. Author manuscript; available in PMC: 2012 Mar 20.
Published in final edited form as: J Immunol. 2011 Feb 25;186(7):3927–3933. doi: 10.4049/jimmunol.1003735

Figure 1.

Figure 1

One dominant and 18 subdominant epitopes define the HSV-specific CD8+ TCR repertoire in the trigeminal ganglion and spleen of C57BL/6 (B6) mice. TG (A, C) and spleens (B, C) from 8 dpi B6 mice were dispersed into single-cell suspensions. Tissues were then incubated for 6 h with peptideloaded B6WT3 fibroblasts in the presence of Golgi-Plug, followed by intracellular staining for IFN-γ. A, Bars represent the mean percentage of TG-resident CD8+ T cells that produce IFN-γ ± SEM (n = 5). B, Bars represent the mean percentage of CD8+ T cells in the spleen that produce IFN-γ ± SEM(n = 5). C, Comparison of HSV-specific CD8+ T cells in the TG and spleen that respond to HSV-1 epitopes. All data are from two independent experiments.