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. Author manuscript; available in PMC: 2012 Mar 20.
Published in final edited form as: J Immunol. 2011 Feb 25;186(7):3927–3933. doi: 10.4049/jimmunol.1003735

Figure 2.

Figure 2

CD8+ T cells specific for subdominant epitopes from 8 dpi TG express granzyme B. Dispersed TG were stained for 1 h at room temperature with anti-CD45, CD8α, and tetramers loaded with sub-dominant epitopes followed by intracellular staining for granzyme B expression. A, Representative dot plots of granzyme B expression of select HSV-specific CD8+ T cells. B, Bars represent percentage of peptide-specific CD8+ T cells that express granzyme B ± SEM (n = 4) from two independent experiments. Granzyme B expression is lower in non-gB-specific CD8+ T cells compared with gB-specific CD8+ T cells. The p value for all specificities is <0.025.