Table 1.

The major functional groups represented by 322 differentially expressed genes at the incubation phase of adjuvant arthritis in Lewis rats^a

Functional group	Number (%)
Innate immunity	19 (5.9%)
Cell markers, innate immune response, complement
Cell-mediated adaptive immune response and effector functions	23 (7.1%)
Stress protein-related and other autoantigens, antigen processing and presentation, T cell costimulation, cytokines and cytokine receptors, activators and regulators
Humoral immunity	8 (2.5%)
Cell proliferation	113 (35.1%)
DNA synthesis, replication, repair, tRNA processing, transcription, translation, cell cycle and cellular components
Cell migration	24 (7.4%)
Adhesion molecules, integrins, chemokines and receptors, cell migration-related
Angiogenesis	2 (0.6%)
Oxygen metabolism related to pathogenesis of arthritis	11 (3.4%)
Transporters of oxygen, electrons, reactive oxygen species, cellular response to oxygen level and oxidation reduction
Articular damage	4 (1.2%)
Metabolism	25 (7.7%)
Glucose metabolism, proteolysis, peptide or amino acid transporter and protein metabolism, lipid metabolism and other metabolic processes
Signal transduction and signaling pathways	16 (5.0%)
Phosphorylation and dephosphorylation, kinase activity and regulation, signal transduction and regulation, G protein-coupled receptor signaling pathway and others
Tumor- and disease-related	8 (2.5%)
Neuron development, neurotransmitters and neuropeptide signaling	4 (1.2%)
Ion binding and transporters, binding activity	7 (2.1%)
Undefined function and unnamed genes	59 (18.3%)

^aDEG: differentially expressed gene; tRNA: transfer RNA. "Immune activity" group includes DEGs in the first three categories: 50 (15.5%).