Table 1.
Altered gene expression in the sensory neurons in dorsal root ganglions in a neuropathic animal model compared to the traumatic disk injury-initiated chronic discogenic pain model
| Tissues | Pain modulator | Neuropathic pain (sciatic nerve ligation)a, reference | Disk degeneration back pain modelb, relative fold induction (n = 12) (P values) |
|---|---|---|---|
| Dorsal horn | Dynorphin | Upregulated [28] | 1.941 ± 0.162 (P < 0.05) |
| NK-1 | Upregulated [29] | 2.512 ± 0.521 (P < 0.05) | |
| DRG | BDNF | Upregulated [23] | 1.841 ± 0.312 (P < 0.05) |
| NPY | Upregulated [24] | 5.367 ± 0.474 (P < 0.05) | |
| CGRP | Downregulated [21] | 0.487 ± 0.433 (P < 0.05) | |
| Substance P | Downregulated [22] | 0.712 ± 0.251 (P < 0.05) | |
| Galanin | Upregulated [25] | 1.1 ± 0.219 (equal) |
BDNF = brain-derived neurotrophic factor; CGRP = calcitonin gene-related peptide; DRG = dorsal root ganglion; NK-1 = neurokinin 1; NPY = neuropeptide Y. aUpregulated and downregulated expression patterns are relative to sham controls. b25-gauge drilling was performed in 12 mice; data are means ± SEM.