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Pharmacodynamic effects of MTRX1011A administration in peripheral blood. Serum levels of soluble CD4-MTRX1011A complexes increased in a dose dependent fashion in the single dose phase (A) and multi-dose phase (B). MTRX1011A administration intravenously (IV) or subcutaneously (SC) lead to significant increase in CD69 expression on memory CD4 T cells in the single dose phase (C) and multi-dose phase (D).
