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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Crit Care Med. 2012 Apr;40(4):1052–1063. doi: 10.1097/CCM.0b013e31823e986a

Figure 2. Principal drivers of inflammation and schematic of a mathematical model of endotoxemia.

Figure 2

Swine were subjected to endotoxemia followed by serial blood sampling and measurement of cytokines and NO2−/NO3− as described in the Materials and Methods. Panel A: Principal Component Analysis (PCA) was carried out on the time courses of all inflammatory analytes. The figure shows the sorted overall PCA score for each inflammatory mediator. Panel B: Schematic of hypothetical trans-compartmental inflammatory interactions inferred from PCA. Panel C: Schematic depicting overall structure of mathematical model of porcine endotoxemia.