Table 1. Hemodynamic and pulmonary function.
Swine (n=4) were subjected to endotoxemia as described in the Materials and Methods. Assessments of hemodynamic and pulmonary function were performed at the indicated time points (in hours).
| BL | 0.5 | 1.0 | 1.5 | 2.0 | 2.5 | 3.0 | 3.5 | 4.0 | 4.5 | 5.0 | 5.5 | 6.0 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR (beats min−1) | 100.5±8.8 | 99.3±10.0 | 110.0±13.4 | 114.8±11.0 | 119.8±16.2 | 118.0±18.2 | 115.3±30.6 | 112.3±26.9 | 109.7±25.6 | 104.0±18.2 | 99.7±14.2 | 98.3±9.3 | 109.7±6.4 |
| MAP (mmHg) | 117.3±4.4 | 98.0±18.9 | 110.8±2.3 | 93.7±6.4 | 72.0±12.6 | 77.3±17.6 | 76.7±12.2 | 82.7±11.1 | 87.7±10.8 | 100.7±8.5 | 109.0±5.0 | 104.3±6.7 | 98.3±16.7 |
| PAP (mm Hg) | 23.3±4.6 | 44.8±2.3 | 36.5±3.8 | 30.3±3.5 | 33.3±3.8 | 37.3±6.4 | 34.3±2.3 | 37.0±1.5 | 37.3±3.3 | 38.7±4.8 | 38.7±4.9 | 36.3±4.2 | 37.3±5.8 |
| CVP (mm Hg) | 6.5±1.3 | 7.0±0.7 | 6.0±1.1 | 4.3±1.1 | 5.8±1.3 | 7.0±2.5 | 5.3±0.9 | 6.0±1.0 | 5.7±0.9 | 5.0±1.0 | 6.0±1.2 | 5.3±1.2 | 5.0±0.6 |
| PAW (mm Hg) | 7.0±1.3 | 9.3±1.2 | 7.3±1.3 | 7.3±2.4 | 8.3±2.3 | 8.0±1.2 | 7.0±0.6 | 9.0±2.1 | 9.7±3.2 | 9.3±1.9 | 8.7±2.7 | 8.3±1.8 | 9.3±1.8 |
| CO (L min−1) | 3.8±0.5 | 2.3±0.5 | 3.4±0.7 | 3.7±0.4 | 2.9±0.6 | 3.2±0.9 | 2.3±0.6 | 2.4±0.3 | 2.7±0.2 | 2.0±0.6 | 1.8±0.6 | 1.5±0.9 | 1.2±0.6 |
| Ppeak (cm H2O) | 22.5±2.6 | 21.5±1.0 | 22.3±1.4 | 25.5±3.6 | 29.3±6.7 | 23.3±2.0 | 24.3±2.1 | 25.7±3.2 | 27.7±4.7 | 28.3±5.5 | 29.3±5.8 | 29.7±6.2 | 30.0±7.0 |
| Pplat (cm H2O) | 18.8±0.8 | 20.3±0.9 | 21.0±1.2 | 23.8±3.3 | 26.8±5.5 | 22.0±1.5 | 23.3±1.2 | 24.3±2.8 | 26.0±4.5 | 26.0±5.1 | 27.7±5.2 | 28.0±5.6 | 28.3±6.4 |
| Pmean (cm H2O) | 6.4±0.5 | 7.3±0.2 | 7.3±0.3 | 7.9±0.8 | 9.9±2.4 | 7.6±0.4 | 7.9±0.5 | 8.5±0.7 | 8.9±1.5 | 8.9±1.6 | 9.0±1.5 | 9.3±1.9 | 9.7±1.6 |
| Cstat (ml cm H2O−1) | 23.7±3.4 | 21.6±3.4 | 20.9±3.9 | 19.4±4.4 | 17.8±4.5 | 19.9±4.3 | 19.1±4.3 | 19.1±4.9 | 18.1±4.6 | 18.4±4.9 | 16.9±4.4 | 17.3±4.7 | 17.0±4.8 |
| Pbladder (mm Hg) | 5.5±1.7 | 4.5±1.6 | 5.8±1.1 | 8.0±3.5 | 6.5±1.2 | 5.3±1.8 | 8.0±1.2 | 7.7±2.3 | 6.0±1.2 | 6.7±2.2 | 5.7±1.3 | 7.5±1.5 | 8.7±1.2 |
| PaO2/FiO2 | 425.5±25.4 | 362.7±30.6 | 370.4±59.4 | 329.1±49.7 | 351.1±66.0 | 334.8±17.4 | 382.1±60.0 | 391.1±57.7 | 366.6±66.2 | 348.3±69.8 | 325.0±82.2 | 312.9±109.1 | 290.9±105.0 |
All data are mean ± SEM. BL = baseline, HR = heart rate, MAP = mean arterial pressure, PAP = pulmonary artery pressure, CVP = central venous pressure, PAW = pulmonary artery wedge pressure, CO = cardiac output, Ppeak= peak airway pressure, Pplat = plateau airway pressure, Pmean = mean airway pressure, Cstat = static lung compliance, Pbladder = bladder pressure.