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Cumulative incidence of diabetes in the KDP.PVG-RT1a/u congenic strain. Under the same specific pathogen-free condition, data of diabetes onset were obtained from the u/u homozygous (n=8), a/u heterozygous (n=19) and a/a homozygous (n=11) animals, all of which harbor the homozygous Cblb mutation. P<0.001 for u/u vs a/u and u/u vs a/a, and P=0.027 for a/u vs a/a by log-rank tests.
