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. 2011 Sep 15;13(2):139–145. doi: 10.1038/gene.2011.63

Figure 2.

Figure 2

Degree of insulitis and thyroiditis in the KDP.PVG-RT1a/u congenic strain at 300 days of age. (A): Representative histology of the pancreas and thyroid glands in the congenic strain. a, normal islet; b, mild insulitis; c, severe insulitis; d, normal thyroid glands; e, mild thyroiditis; f, severe thyroiditis. (B) The degree of insulitis and thyroiditis in the congenic strain shortly after the onset of diabetes or at 300 days of age for non-diabetic animals. Data were obtained from the u/u homozygous (n=8), a/u heterozygous (n=19) and a/a homozygous (n=11) animals, all of which harbor the homozygous Cblb mutation. Insulitis: P=0.017 for u/u vs a/u, P<0.001 for u/u vs a/a and P=0.020 for a/u vs a/a; Thyroiditis: P=0.050 for u/u vs a/u, P=0.016 for u/u vs a/a and P=0.573 for a/u vs a/a by Mann–Whitney U tests.