Figure 4.
Degree of insulitis and thyroiditis in the PVG.KDP-Cblb congenic strain at 300 days of age. The degree of insulitis and thyroiditis in each animal was evaluated at 300 days of age. Data were obtained from the animals homozygous (n=21), heterozygous (n=10) and wild type (n=10) for the Cblb mutation. P=0.082 for insulitis and P=0.249 for thyroiditis by Mann–Whitney U tests in comparison between the a/a homozygous animals in the KDP.PVG-RT1a/u congenic strain and the Cblb homozygous mutants in the PVG.KDP-Cblb congenic strain.