Table 2. Uptake, Elimination, and Biotransformation Rate Constants with 95% Confidence Intervals (CI)^a.

	parent		M1		M2		M3
compound (n = # of internal concentration data points, df = degrees of freedom)b	kin_parent [95% CI] L × kg–1 × d–1	kout_parent [95% CI] d–1	kmet1 [95% CI] d–1	kloss_M1 [95% CI] d–1	kmet2 [95% CI] d–1	kloss_M2 [95% CI] d–1	kmet3 [95% CI] d–1	kloss_M3 [95% CI] d–1
aldicarb (n = 28, df = 24)	9.86 [6.8; 12.9]	9.31 [5.1; 13.6]	2.05 [0.8; 3.3]	6.19 [2.3; 10.0]
carbofuran (n = 36, df = 32)	4930 [0; 595904]	7063 [0; 878858]	16.22 [0; 32.6]	0.16 [0.12; 0.20]
carbaryl (n = 40, df = 37)	23.4 [n.a.]c	2.258 [1.4; 3.1]	3.36 [2.4; 4.4]	0.09 [0.05; 0.13]
malathion (n = 36, df = 32)	8.86 [4.4; 13.3]	0 [0; 3.1]	2.99 [1.1; 4.9]	1.91 [0.5; 3.3]
pentachlorophenol (n = 40, df = 36)	646 [143; 1149]	0 [0; 5.5]	3.19 [0; 6.7]	2.03 [0; 4.6]
chlorpyrifos (n = 45, df = 39)	1499 [1072; 1926]	0 [0; 2.4]	3.50 [1.9; 5.1]	2.93 [1.5; 4.4]	0.132 [0; 0.4]	0.298 [0; 1.8]
2,4-dichloroaniline (n = 42, df = 36)	293 [82; 504]	8.23 [0.4; 16.0]	0.949 [0.6; 1.3]	0.478 [0.05; 0.90]	0.799 [0.2; 1.4]	1.07 [0; 2.2]
2,4-dichlorophenol (n = 60, df = 54)	723 [0; 6343]	153 [0; 1478]	19.62 [0; 43]	0.413 [0.34; 0.49]	3.17  [0; 8.2]	0.911 [0; 2.3]
2,4,5-trichlorophenol (n = 54, df = 48)	1389 [0; 4073]	0 [0; 36]	14.52 [1.1; 28.0]	0.822 [0.42; 1.23]	2.35 [0; 9.7]	1.78 [0; 9]
4-nitrobenzyl-chloride (n = 56, df = 49)	576 [n.a.]c	31.23 [0; 90]	0.86 [0; 4.2]	0.278 [0; 3.4]	42.5 [0; 111]	4.13 [2.2; 6.1]	44.3 [0; 115]	2.46 [1.8; 3.2]
sea-nine (n = 80, df = 72)	345 [295; 395]	0 [0; 1.1]	0.349 [0; 1.2]	2.70 [0; 9.8]	0.623 [0.5; 0.8]	0.536 [0.34; 0.73]	0.299 [0; 0.9]	2.18 [0; 7.4]

^aConfidence intervals extending below zero were truncated at zero.

^bThe raw data used for modeling is available as Supporting Information.

^cThe uptake rate constants k_in for carbaryl and 4-nitrobenzyl-chloride were kept fixed to previously measured values.¹¹