Table 3.
Volunteer ratings on two mystical experience questionnaires completed 7 hours after drug administration and at 14 month follow-up*
| Questionnaire and Subscale Description |
7 Hours after Drug Administration | 14 Month Follow-up (30 mg/70 kg) ‡ |
||||
|---|---|---|---|---|---|---|
| Psilocybin Dose (mg/70 kg) | ||||||
| 0† | 5† | 10† | 20† | 30† | ||
| States of Consciousness Questionnaire | ||||||
| Internal unity | 15.2 (4.6) | 38.0 (6.7)a | 44.6 (5.07)a | 64.4 (6.0)b | 70.2 (6.2)b | 76.5 (6.4) |
| External unity | 12.4 (3.7) | 32.6 (6.0)a | 35.0 (6.0)a | 53.3 (5.6)b | 60.7 (6.7)b | 63.5 (7.4) |
| Sacredness | 23.7 (5.5) | 48.7 (6.9)a | 54.0 (6.4)a | 71.1 (5.8)b | 77.1 (6.4)b | 83.3 (4.7) |
| Noetic Quality | 19.4 (5.3) | 47.5 (6.7)a | 54.4 (5.8)a,b | 65.3 (6.0)b,c | 70.6 (6.5)c | 76.9 (6.4) |
| Transcendence of time and space | 18.3 (4.8) | 40.4 (6.8)a | 44.4 (5.6)a | 65.4 (6.2)b | 78.2 (5.2)c | 82.6 (5.2) |
| Deeply felt positive mood | 26.8 (4.7) | 47.6 (5.4)a | 57.5 (6.3)a,b | 68.3 (5.5)b,c | 73.2 (6.5)c | 77.3 (5.7) |
| Ineffability | 19.3 (6.0) | 48.4 (6.3)a | 59.1 (5.8)a | 73.1 (6.6)b | 81.3 (6.0)b | 81.1 (4.6) |
| Total | 21.0 (4.7) | 45.1 (5.9)a | 52.0 (5.2)a | 68.3 (5.0)b | 75.6 (5.4)b | 80.1 (4.9) |
| Mysticism Scale | ||||||
| Interpretation | 57.1 (6.5) | 83.5 (5.3)a | 84.1 (5.2)a | 95.7 (3.7)b | 99.1 (2.6)b | N/A |
| Introvertive | 54.4 (7.1) | 77.6 (6.2)a | 79.7 (5.1)a | 93.0 (3.7)b | 97.4 (3.4)b | N/A |
| Extrovertive | 30.7 (4.7) | 48.2 (4.7)a | 49.4 (5.0)a | 57.1 (3.9)b | 61.3 (3.8)b | N/A |
| Total (max score=288) | 142.2 (17.7) | 209.2 (15.4)a | 213.2 (14.4)a | 245.8 (9.0)b | 257.9 (8.9)b | N/A |
Data are mean scores with 1 SEM shown in parentheses (N=18); data for the States of Consciousness Questionnaire are expressed as a percentage of the maximum possible score
Data in these columns show rating data 7 hours after the indicated dose of psilocybin; within the same row for these columns, bold font indicates significant difference from 0 mg/70 kg; for active doses, values not sharing a common letter are significantly different (Fisher’s LSD p<0.05)
For the States of Consciousness Questionnaire, data in this column show ratings of the 30 mg/70 kg session experience at the 14 month follow-up; each value in this column was significantly greater than the value at 0 mg/70 kg after 7 hours (as indicated by bold font) but was not different from the value at 30 mg/kg 1 month (Fisher’s LSD p<0.05); 14 month follow-up data were not obtained for the experience-specific version of the Mysticism Scale (indicated by N/A), although data were obtained for the Lifetime version (see text)