Table 5.
Percentage of volunteers endorsing specific outcomes on four persisting effects items 1 month and 14 months after sessions*
| Questionnaire Items | 1 Month after Sessions | 14 Month Follow-up (20 or 30 mg/70 kg)** |
|||||
|---|---|---|---|---|---|---|---|
| Psilocybin Dose (mg/70 kg) | |||||||
| 0† | 5† | 10† | 20† | 30† | 20 or 30‡ | ||
| How personally meaningful was the experience? | |||||||
| Single most meaningful experience of life | 0.0 | 0.0 | 5.6 | 16.7 | 33.3 | 44.4 | 38.9 |
| Top 5 most meaningful, including single most | 0.0 | 11.1 | 33.3 | 77.8 | 61.1 | 77.8 | 94.4 |
| How spiritually significant was the experience? | |||||||
| Single most spiritually significant experience of life | 0.0 | 0.0 | 5.6 | 27.8 | 44.4 | 61.1 | 44.4 |
| Top 5 most spiritually significant, including single most | 11.1 | 11.1 | 44.4 | 66.7 | 77.8 | 83.3 | 94.4 |
|
Did the experience change your sense of well-being or
life satisfaction? |
|||||||
| Increased well-being/life satisfaction (very much) | 5.6 | 27.8 | 38.9 | 72.2 | 55.6 | 77.8 | 61.1 |
| Increased well-being/life satisfaction (moderately or very much) | 38.9 | 55.6 | 72.2 | 83.3 | 88.9 | 94.4 | 83.3 |
|
Your behavior changed in ways you would consider positive since the experience. |
|||||||
| Positive behavioral change (strong or extreme) | 22.2 | 16.7 | 50.0 | 38.9 | 55.6 | 55.6 | 44.4 |
| Positive behavioral change (moderate, strong or extreme) | 33.3 | 50.0 | 61.1 | 61.1 | 88.9 | 88.9 | 88.9 |
Data in table show the percentage of volunteers endorsing the specific outcome
Data in these columns are the percentage of volunteers endorsing the specific outcome 1 month after the indicated dose of psilocybin; within the same row for these columns, bold font indicates significant difference in pair-wise comparisons to 0 mg/70 kg (Cochran’s Q showed p<.001 for all variables; planned comparisons performed with Wald test; see Methods for details)
Data in this column are the percentage of volunteers endorsing the specific outcome 1 month after either or both the 20 and 30 mg/70 dose sessions; bold font indicates significant difference in pair-wise comparisons to 0 mg/70 kg (Cochran’s Q showed p<.05 for all variables; planned comparisons performed with Wald test; see Methods for details)
Data in this column are the percentage of volunteers at 14 month follow-up endorsing the specific outcome with respect to experiences during either or both the 20 and 30 mg/70 kg dose sessions (see Methods); each value in this column was significantly greater than the value at 0 mg/70 kg (as indicated by bold font) but was not significantly different from the value at 20 or 30 mg/kg at 1 month (Cochran’s Q showed p<.05 for all variables; planned comparisons performed with Wald test; see Methods for details)