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Epithelial β-catenin indirectly regulates expression of genes in the mesenchymal cells. Whole-mount RNA in situ hybridization using Lhx7 and Msx1 probes. A,B: Wild-type controls. C,D: Epithelial-specific β-catenin loss-of-function (β-cat, LOF) mutants. E,F: β-catenin gain-of-function (β-cat, GOF) mutants. black arrowhead, normal expression pattern; white arrowhead, reduced expression; red arrowhead, increased expression.
