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. 2012 Jan 4;96(4):597–603. doi: 10.1136/bjophthalmol-2011-300831

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© 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

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(A) Fundus photographs (a) before and (b) 5 weeks after surgery. After surgery, distinct subretinal arcuate discolouration is present in the superior and inferior temporal arcuate zone (white arrows) and a marginal dark halo around the disc (black arrowheads) and a normal macula (black arrow) are seen (b). Retinal vascularity is unchanged. (B) Immunostaining of phosphorylated neurofilaments in a frontal section. Diffuse deterioration of SMI-31-positive axons (DABni) is evident in the temporal (T) arcuate zone, with the exception of a row in the innermost marginal bundles. (C) Immunostaining (DABni) of sagittal sections reveals a clear difference in phosphorylated (a) and non-phosphorylated (b) neurofilament reactivity. The number of SMI-31-positive bundles decreased in the optical nerve head and lamina cribrosa in the temporal division (black arrow), in clear contrast to the nasal half (Ca). SMI-32-positive profiles in temporal bundles (black arrow) cannot be distinguished from those in nasal bundles in ONH (Cb). Expression of gliosis by glial fibrillary acidic protein increased in the temporal half (black arrow) (Cc). (D) Double staining by SMI-31 with glial fibrillary acidic protein of a frontal section demonstrates the markedly decreased diameter of phosphorylated bundles (Rhodamine 555), with widened columns and glial proliferation (Alexa 488), in the temporal arcuate zone.