Table 3. Hypermethylated Loci Previously Identified in Breast Cancers.
| Gene symbol | Published | Hyper methylated in other cancers | Known aberrant expression | Gene | Location | Ref |
|---|---|---|---|---|---|---|
| EVI1 (MECOM) | ER-POS (25) | NO | BASAL (38) | MDS1 and EVI1 complex locus | Nucleus | (25, 38, 39) |
| ETS1 | ER-POS (25) | BASAL (37) | v-ets erythroblastosis virus E26 oncogene homolog 1 | Nucleus | (37) | |
| IRF7 | ER-POS (25) | YES | interferon regulatory factor 7 | Nucleus | ||
| LYN | ER-POS (25) | YES | BASAL (37, 40, 41) | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | Cytoplasm | (25, 37, 40, 41) |
| PDXK | ER-POS | NO | NO | pyridoxal kinase (vitamin B6 kinase) | Cytoplasm | (29) |
| PTGS2 (COX2) | ER-POS (25) | YES | BASAL (37) | prostaglandin-endoperoxide synthase 2 | Cytoplasm | (25, 37) |
| RUNX3 | ER-POS (42) | YES | BASAL (37) | runt-related transcription factor 3 | Nucleus | (37, 42) |
| VIM | ER-POS | YES | BASAL (40) | vimentin | Cytoplasm | (40) |
| DAB2IP (4 LOCI) | ER-NEG (25) | YES | DAB2 interacting protein | Plasma Membrane | (25) | |
| HSD17B4 | ER-NEG (43) | YES | ER POS (43) | hydroxysteroid (17-beta) dehydrogenase 4 | Cytoplasm | (43) |
| PER1 | ER-NEG (23) | period homolog 1 (Drosophila) | Nucleus | (23) |