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. 2012 Mar 19;196(6):727–742. doi: 10.1083/jcb.201107096

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© 2012 Ryan et al.

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Figure 6. — Loss of dystonin-a2 alters Golgi morphology. (A) VSVG localizes with cis-Golgi marker GM130 despite inability to traffic in 293T cells deficient in dystonin-a2. (B and C) Loss of dystonin-a2 in 293T cells promotes Golgi fragmentation (Student’s t test; n = 3). (A and B) Arrows depict compact Golgi, whereas arrowheads depict dispersed Golgi. (D) Electron micrograph of P4 and P15 WT and dt^27J DRG sections show dilated Golgi in sensory neurons of dt^27J mice. Arrowheads depict the cis-Golgi face, whereas asterisks depict dilated Golgi vesicles. (E–G) Ultrastructural analysis of dt^27J Golgi showed increased area at P4 and P15 relative to WT littermates and an increase in the number of dilated Golgi per animal (Student’s t test; n = 4). Error bars show means ± SEM. Cont, control; M, mitochondria; RER, rough ER. **, P < 0.01. Bars: (A and B) 10 µm; (D) 500 nm.