Table 1.
Selected GO biological processes significantly enriched among genes down-regulated in prephenotype DRGs from dt27J mice
| Category | Targets | P-value | Fold enrichment | Example gene products |
| Transport | 561 | 4.30 E−20 | 1.4 | DLC2, KCL2, and DNM1 |
| Vesicle-mediated transport | 125 | 8.90 E−08 | 1.7 | DNM1, CLTB, and HTT |
| Cytoskeleton organization | 77 | 6.50 E−03 | 1.5 | DNAHC9, MAPT, and TUBGCP2 |
| Synaptic transmission | 76 | 4.30 E−15 | 2.7 | APBA1, CDK5, and KIF1B |
| Neurotransmitter secretion | 21 | 3.30 E−06 | 3.7 | SYN1, SYN2, and VAMP2 |
| MT bundle formation | 14 | 3.70 E−04 | 4.5 | TPPP, MAP1B, and SPAST |
The p-values given are using Fisher’s exact test with correction for multiple hypothesis testing by the algorithm of Benjamini and Hochberg (1995). The background set of genes used was the entire mouse genome.