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. 2012 Jan 19;287(12):9147–9167. doi: 10.1074/jbc.M111.316554

FIGURE 2.

FIGURE 2.

Cell type-specific role of SP-STP in mediating apoptosis. A, comparison of the ability of the wild-type (M1SF370 and M1T15448), isogenic nonpolar SP-STP-knock-out mutants (M1ΔSTP and M1T1ΔSTP), and the STP mutants complemented with the stp gene (M1ΔSTP::stp and M1T1ΔSTP::stp) (14) to inhibit proliferation of Detroit 562 cells infected at a multiplicity of infection of 100:1 (GAS CFUs:Detroit 562 cells) as revealed by MTT assay. B, MTT assay demonstrating the dose-dependent effect of the purified recombinant SP-STP and EF-STP on the proliferation of pharyngeal cells. MTT assay demonstrating the dose-dependent effect of the purified recombinant SP-STP on the proliferation of Cal-27 (C) and HepG2 cells (D).