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TUNEL assay and histopathology of lungs of mice infected with wild-type (M1SF370) and isogenic mutant (M1ΔSTP) GAS strains. A, TUNEL and H&E staining of lungs of mice infected (intravenous or intranasal) with M1SF370 or M1ΔSTP (red arrows/arrowheads) show representative TUNEL-positive alveolar cells in brown. B, average TUNEL-positive cells per field obtained from three independent tissue sections.
