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. 2012 Jan 30;287(12):8904–8911. doi: 10.1074/jbc.M111.325803

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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FIGURE 1. — Interface between SARS-CoV RBD and hACE2. A, list of mutations in the RBMs of various SARS-CoV strains. Five representative existent strains and two predicted future strains are defined in the Introduction. B, overall structure of the hTor02 RBD-hACE2 complex (Protein Data Bank code 2AJF). hACE2 is in green, and hTor02 RBD is in cyan (core) and red (RBM). RBM residues that underwent mutations are displayed. C, detailed structure of the hTor02 RBD/hACE2 interface. hACE2 residues are in green, SARS-CoV residues that underwent mutations are in magenta, and SARS-CoV residues that played significant roles in the mutations are in cyan.