TABLE 1.

Effects of Isa protein depletion on various mitochondrial Fe/S proteins

[2Fe-2S] proteins (maturation normal)	[4Fe-4S] proteins (no maturation)	Complex Fe/S proteins (enzymes inactive)
Isu1a	Aconitase (Aco1)	Biotin synthase (Bio2) ([2Fe-2S], [4Fe-4S], AdoMet)
Rieske Fe/S	Homoaconitase (Lys4)	Lipoic acid synthase (Lip5) ([4Fe-4S], [4Fe-4S], AdoMet)
Ferredoxin (Yah1)		Succinate dehydrogenase (Sdh2) [2Fe-2S], [3Fe-4S], [4Fe-4S]
Ilv3b
[2Fe-2S] ferredoxinc	HiPIPc

^a See Ref. 63.

^b See Ref. 65 and supplemental Fig. S1.

^c Mitochondrial matrix-targeted bacterial Fe/S proteins.