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. 2011 Sep 14;286(48):41368–41380. doi: 10.1074/jbc.M111.286690

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Deletion of STP attenuates GAS virulence in an experimental mouse intraperitoneal infection model. Effects of the deletion of the stp gene on GAS virulence of CD-1 mice (n = 10) as observed for the wild-type and mutant strains of M1SF370 (A) and M1T1 (B). Survival/mortality for the strains was monitored for 10 days, and the data were statistically evaluated and analyzed by the log rank test using GraphPad Prism 4 software. For real-time (qRT-PCR) analysis, the expression profiles of 19 virulence-related genes, 13 metabolism-related genes, and the other six one-/two-component transcription regulators in the stp-deleted mutant strains derived from M1SF370 (C) and M1T1 (D) were compared with respect to their corresponding wild-type strains. The transcripts were quantified by a SYBR Green-based real-time PCR assay as described under “Experimental Procedures.” The gray zone across the y axis depicts the threshold for determining significant (≥2-fold) change.