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In vivo virulence of the STP mutants complemented with high copy (pDC123) and low copy (pREG696 and pJRS9508) plasmids. Effects of the stp complementation on GAS virulence in CD-1 mice (n = 10) for the wild-type and complemented strains of M1SF370 (A) and M1T1 (B) are shown. Survival/mortality for the strains was monitored for 10 days, and the data were statistically analyzed as described above in the legend to Fig. 6.
