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. 2011 Sep 27;286(48):41510–41519. doi: 10.1074/jbc.M111.275396

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Crystal structure of yCT and yCT-H9 complexed with compound 2. A, Compound 2 bound to yCT (green) crystal structure (RCSB entry code 3H0J) showing interactions of the two amide oxygens with the backbone NH of Glu-2026 and Gly-1958 as dashed lines. B, binding mode of compound 2 to yCT-H9 (cyan) crystal structure is shown. Note the altered orientation of the methylquinoline moiety, which has shifted by ∼180° relative to that seen in 3H0J. The structure of Compound 2 is depicted as green or cyan sticks.