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Crystal structure of yCT and yCT-H9 complexed with compound 3. A, compound 3 bound to yCT (green) crystal structure (RCSB entry code 3H0Q). Interactions of the two amide oxygens with the backbone NH of Glu-2026 and Gly-1958 are shown as dashed lines. B, compound 3 bound to yCT-H9 (cyan) crystal structure. As in the case of compound 2, the methylquinoline is rotated by ∼180° between the yCT and yCT-H9 structures. The structure of compound 3 is depicted as green or cyan sticks.
