TABLE 3.

Thermal stability of the variant proteins upon treatment with compounds

T_m values were determined from a protein thermal stability assay using SYPRO orange as the reporter dye.

Sample	yCT		hCT		yCT-H9
	Tm	ΔTm	Tm	ΔTm	Tm	ΔTm
	° C	° C	° C	° C	° C	° C
Apo	44		54		43
Apo + compound 1	35/47	−9/3	65	11	59	16
Apo + compound 4	40	−4	56	2	47	4