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TP0453 increases efflux of fluorophore in LUVs at acidic pH. The graphs show pH-dependent quenching of Tb(DPA)33− from the encapsulated LUVs, after incubation with TP0453. Pore formation at pH 7.0 by E. coli OmpF was used as a positive control. The fractions quenched were determined as described under “Experimental Procedures.” The inset represents initial kinetic profiles for quenching of Tb(DPA)33− from the encapsulated LUVs at different pH values.
