TABLE 1.
Integration frequency near mapped genomic features in the human genome
Integration sets generated in this study and their genomic distributions are shown. Significant deviation from LEDGF BC in a Mann-Whitney test is shown.
| Cell line | No. sites | % in RefSeq genes | % <4-kb CpG island | |
|---|---|---|---|---|
| EIAV sites | WT | 717 | 71.8 | 2 |
| KD | 448 | 52a | 5.6b | |
| LEDGF BC | 862 | 74.8 | 2.8 | |
| LEDGFD366A | 454 | 60.4a | 5.5c | |
| ΔN93-LEDGF | 157 | 51.6a | 8.3a | |
| PWWPHDGF-LEDGF | 610 | 73.1 | 3.4 | |
| PWWPHRP2-LEDGF | 802 | 79.4c | 2.5 | |
| HDGF-LEDGF325–530 | 873 | 84.1a | 4.8c | |
| MRC sites | MRC WT | 2151 | 40.6 | 3.3 |
| MRC KD | 1344 | 39.3 | 2.8 | |
| MRC LEDGF BC | 2586 | 40.6 | 2.6 | |
| MRC LEDGFD366A | 1362 | 40.8 | 2.9 | |
| MRC ΔN93-LEDGF | 471 | 43.1 | 3.4 | |
| MRC PWWPHDGF-LEDGF | 1827 | 38.5 | 3.7 | |
| MRC PWWPHRP2-LEDGF | 2406 | 38.6 | 2.4 | |
| MRC HDGF-LEDGF325–530 | 2619 | 41.8 | 3.2 |
a p < 0.001.
b p < 0.01.
c p < 0.05.