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T863 enhanced insulin-stimulated glucose uptake in differentiated 3T3-L1 adipocytes. Differentiation of 3T3-L1 cells to adipocytes, compound treatment, and insulin-stimulated glucose uptake test are described under “Experimental Procedures.” Data represent mean ± S.E. (error bars) obtained from three independent experiments, each performed in triplicate. *, p < 0.05 versus vehicle.
