Figure 2.

Soluble HLA class I molecules inhibit antigen-presenting properties of MDDC. (A-B): Soluble HLA class I molecules block allostimulatory activities of MDDC. MDDC were stimulated with plasma from HIV-1 progressors, elite controllers or HIV-1 negative persons with or without prior depletion of soluble HLA class I molecules. Subsequently, MDDC were mixed with allogeneic T cells. Data reflect proportions of proliferative allogeneic T cells (A) and correlations between proliferative allogeneic T cell responses and corresponding quantities of soluble HLA class I isoforms in the plasma (B).