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Soluble HLA class I molecules inhibit functional properties of MDDC through interactions with LILRB2. (A): Data indicate allostimulatory properties of MDDC after exposure to plasma from HIV-1 progressors in the presence of recombinant soluble LILRB2 or control protein. (B): Allostimulatory properties of MDDC after exposure to HLA class I-deficient or -proficient plasma from progressors in the presence or absence of siRNA-mediated LILRB2 silencing.
