Table 1. Daily and group mean neurologic scores of animals inoculated IT.
Group | Animal # | Clinical Scores | |
Daily Mean | Group Mean | ||
Vehicle Control | 53-09 | 0 | 0 |
60-09 | 0 | ||
68-01 | 0 | ||
359-09 | 0 | ||
rVSV-wt | 56-09* | 2.8 | 2 |
67-01** | 3.2 | ||
362-09 | 0 | ||
rVSV-ZEBOV-GP | 352-09 | 0 | 0 |
354-09 | 0 | ||
357-09 | 0 | ||
358-09 | 0 | ||
360-09 | 0 | ||
361-09 | 0 | ||
363-09 | 0 | ||
rVSV-MARV-GP | 52-09 | 0 | 0 |
57-09 | 0 | ||
59-09 | 0 | ||
61-09 | 0 | ||
355-09 | 0 | ||
356-09 | 0 | ||
364-09 | 0 |
0 = No clinical signs of encephalitis; 1 = Rough coat, not eating; 2 = High pitch vocalization, inactive, slow moving; 3 = Shaky movements, tremors, incoordination, limb weakness; 4 = Inability to stand, limb paralysis, moribund.
*: 56-09 was euthanized at day 6 post inoculation with a clinical score of 3. The animal was assigned a clinical score of 4 for the remainder of the 21 day experimental period.
**: 67-01 was euthanized at day 5 post inoculation with a clinical score of 3. The animal was assigned a clinical score of 4 for the remainder of the 21 day experimental period.