Table 4. Histopathological scores from left/right hemisphere of the brain and spinal cord.
Group | Animal # | Day PI | FC | BG | TH | OC | CB/BS | SC |
Vehicle Control | 53-09 | 21 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0 |
60-09 | 21 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0 | |
68-01 | 21 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0 | |
359-09 | 21 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0 | |
rVSV-wt | 56-09* | 6 | 4/4 | 4/4 | 3/2 | 1/1 | 2/2 | 3 |
67-01** | 5 | 2/3 | 2/1 | 0/0 | 0/0 | 0/1 | 1 | |
362-09 | 21 | 4/1 | 1/1 | 1/1 | 0/0 | 0/2 | 3 | |
rVSV-ZEBOV-GP | 352-09 | 21 | 1/1 | 1/0 | 1/0 | 0/0 | 0/0 | 0 |
354-09 | 21 | 1/1 | 0/0 | 1/0 | 0/0 | 0/0 | 0 | |
357-09 | 21 | 1/0 | 0/0 | 0/0 | 0/0 | 1/0 | 0 | |
358-09 | 21 | 0/0 | 1/0 | 1/0 | 0/1 | 0/0 | 0 | |
360-09 | 21 | 1/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0 | |
361-09 | 21 | 1/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0 | |
363-09 | 21 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0 | |
rVSV-MARV-GP | 52-09 | 21 | 0/1 | 1/0 | 1/0 | 0/0 | 0/0 | 0 |
57-09 | 21 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0 | |
59-09 | 21 | 1/0 | 0/0 | 1/0 | 0/0 | 0/0 | 0 | |
61-09 | 21 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0 | |
355-09 | 21 | 1/0 | 1/4 | 0/0 | 0/0 | 0/0 | 0 | |
356-09 | 21 | 1/1 | 0/0 | 0/0 | 0/0 | 0/0 | 0 | |
364-09 | 21 | 1/0 | 0/0 | 0/1 | 0/0 | 0/1 | 0 |
Left score #/Right score #; Scores; 0 = no lesions, 1 = minimal perivascular inflammatory infiltrate, no gliosis, no neurodegeneration, no satellitosis, and no necrosis, 2 = mild perivascular inflammatory infiltrate, mild gliosis, no neurodegeneration, no satellitosis, and no necrosis, 3 = moderate inflammatory infiltrate with moderate gliosis, mild neurodegeneration, mild satellitosis, and mild necrosis, and 4 = severe inflammatory infiltrate with moderate to severe gliosis, neurodegeneration, satellitosis, and necrosis.
FC = frontal cortex, BG = basal ganglia, TH = thalamus, OC = occipital cortex, CB/BS = cerebellum/brain stem, SC = spinal cord; PI = post-inoculation.