Table 1. Association of HLA-DPA1 variant rs3077 and HLA-DPB1 variant rs9277535 with HBV infection.
rs3077 | Cases, n (%) | Controls, n (%)* | Recessive model | Dominant model | ||||||
Phenotype** | TT | TC | CC | TT | TC | CC | OR (95% CI) | p | OR (95% CI) | p |
HBV infection vs. healthy controls | 125 | 55 | 21 | 148 | 69 | 5 | 5.1 (1.9–13.7) | 0.00093 | 1.2 (0.8–1.8) | 0.67 |
0.62 | 0.27 | 0.10 | 0.67 | 0.31 | 0.02 | |||||
CHB infection vs. inactive HBsAg carriers (controls) | 31 | 8 | 7 | 30 | 15 | 3 | 2.7 (0.6–11.1) | 0.31 | 0.8 (0.3–1.9) | 1 |
0.67 | 0.17 | 0.15 | 0.63 | 0.31 | 0.06 |
controls include either healthy subjects with negative serological HBV markers (vs. HBV patients) or inactive HBsAg carriers in the subgroup analysis of patients with HBV infection (vs. active CHB patients);