Figure 1. Serotonin 2C receptor gene structure.

A) The human full-length 5-HT_2C gene, located on the X chromosome and processed from mRNA encoded from exon 3 to exon 6 after splicing out intronic sequence is depicted (not including 3′- or 5′- untranslated regions and not according to scale). B) The 5-HT_2C gene is translated into a seven-transmembrane G-protein coupled receptor. The editing cassette is located in the second intracellular loop. C) The nucleotide sequence of the 5-HT_2C editing cassette is depicted including the five nucleotide positions prone to adenosine to inosine editing.