Figure 4. Central serotonin (5-HT) receptor mRNA expression.

A) 5-HT_1A mRNA is increased in ob/ob mice in hippocampus and hypothalamus. B) 5-HT_1B mRNA is increased in ob/ob mice in hippocampus. C) 5-HT₆ mRNA is increased in ob/ob mice in hippocampus. D) No change in mRNA levels of total 5-HT_2C mRNA measured using qRT-PCR relative to β-actin expression. Fold changes depicted compared to hippocampus in control group. Unpaired, two-tailed T-test; statistical significance is notated as *** p<0.001, ** p<0.01, * p<0.05 compared to lean control; n = 7–8 per genotype.