Figure 6. 5-HT_2C receptor editing in the hippocampus.

Expression of 5-HT_2C receptor isoforms in order of fully unedited isoform to fully edited 5-HT_2C receptor isoform. A) Decreased expression of the unedited 5-HT_2C-INI isoform in hippocampus of ob/ob mice, but not statistically significant. B) Significantly increased expression of the edited 5-HT_2C-VNV (ABD edited) isoform in hippocampus of ob/ob mice. C) No change in mRNA levels of 5-HT_2C-VSV (ABCD edited) isoform. D) No change in mRNA levels of the 5-HT_2C-VGV (ABECD edited) isoform. All mRNA measured using qRT-PCR relative to β-actin expression and depicted as fold change compared to lean control littermates. Unpaired, two-tailed T-test; statistical significance is notated as ** p<0.01, compared to lean control; n = 7–8 per genotype.