Figure 7. 5-HT_2C receptor editing in the hippocampus.

Editing of hippocampal the 5-HT_2C receptor was pinpointed to nucleotide position A and B using direct sequencing. A) Column scatter plot of editing frequencies on site A and B of the editing cassette. B) A typical reverse complement chromatogram trace of an ob/ob mouse is depicted. Specific editing positions A to E are indicated by arrows. C) A typical control chromatogram is depicted. Unpaired, two-tailed T-test; statistical significance is notated as * p<0.05, compared to lean control; n = 5 per genotype.