Table 3. Risk of Death Associated with Baseline Biomarker Levels.

Biomarker	Type of analysis	<25th percentile (Reference)	25–49th percentile		50–74th Percentile		≥75th Percentile		OR associated with 1 IQR higher biomarker level
			OR (95% CI)	p-value	OR (95% CI)	p-value	OR (95% CI)	p-value	OR (95% CI)	p-value
hsCRP	Univariate	1.0	1.2	0.64	2.0	0.02	4.9	<0.0001	3.0	<0.0001
			(0.6–2.1)		(1.1–3.4)		(2.8–8.5)		(2.2–4.2)
	Adjusted	1.0	1.1	0.79	1.7	0.10	3.5	0.0001	2.5	<0.0001
			(0.5–2.2)		(0.9–3.1)		(1.9–6.7)		(1.7–3.6)
D-Dimer	Univariate	1.0	1.4	0.26	2.2	0.008	3.8	<0.0001	5.8	<0.0001
			(0.8–2.5)		(1.1–3.8)		(2.2–6.6)		(3.1–10.8)
	Adjusted	1.0	1.2	0.55	1.5	0.19	2.6	0.002	4.0	<0.0001
			(0.6–2.3)		(0.8–2.8)		(1.4–4.9)		(2.0–7.9)
IL-6	Univariate	1.0	2.1	0.04	2.8	0.003	5.5	<0.0001	3.7	<0.0001
			(1.0–4.2)		(1.4–5.6)		(2.8–10.7)		(2.3–5.8)
	Adjusted	1.0	1.7	0.14	1.9	0.08	3.8	0.0004	2.8	<0.0001
			(0.8–3.6)		(0.9–4.0)		(1.8–7.8)		(1.7–4.6)

Odds ratios are derived from separate conditional logistic regression models for each biomarker (two unadjusted univariate and two adjusted models for each biomarker, one with quartiles and one with continuous level of biomarker after log₁₀ transformation); adjusted models include HIV disease state, hemoglobin, platelet, aspartate aminotransferase, and white blood cell count (dichotomized at the median). Percentile cut-off points (IQR on log10 scale) are hsCRP: <1.80, 1.80–5.15, 5.15–20.05, ≥20.05 (0.36–1.31); D-dimer: <0.71, 0.71–1.11, 1.11–1.92, ≥1.92 (0.15–0.28); IL-6: <2.14, 2.14–4.92, 4.92–11.22, ≥11.22 (0.33–1.05).