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. 2012 Mar 20;7(3):e33498. doi: 10.1371/journal.pone.0033498

Figure 4. Deletion of THO complex components Hpr1p or Tho2p enhances the telomere position effect.

Figure 4

(A) tho2 enhances the telomere position effect. Wild-type or tho2 cells with URA3 at 1.1 kbp (UCC507), 2.5 kbp (UCC509), or 5.5 kbp (UCC511) from the telomere of chromosome VII–L were analyzed. Cells in 10-fold serial dilutions were spotted on YC, YC lacking uracil, or plates containing 5-FOA, and incubated until colonies formed. (B) THO2 and HPR1 function in the same pathway as RIF1 to regulate the telomere position effect. Samples of serial dilutions of UCC509 cells with the indicated mutations were spotted on plates as indicated.