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. 2012 Mar 20;7(3):e33750. doi: 10.1371/journal.pone.0033750

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Vasquez-Rifo et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Amino acid sequence alignment between ALG-1 and ALG-2 proteins (77% identity and 81% similarity). Identical (black) and similar (grey) residues as well as the PAZ (pink) and PIWI (blue) signature domains are indicated. (B) Neighbor joining tree of nematodes and human AGO-clade Argonautes based on the conserved sites from an alignment of full length protein sequences. With the exception of human AGO1 and AGO3 (*), all the subtrees are robustly significant (higher than 95% bootstrap; 500 trials). Ce, Caenorhabditis elegans; Cb, Caenorhabditis briggsae; Hs, Homo sapiens.