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. 2012 Mar 20;7(3):e33961. doi: 10.1371/journal.pone.0033961

Figure 4. CB2 agonism inhibits SDF-1á mediated G-protein coupling to CXCR4.

Figure 4

(A–B) GTPãS binding following addition of the CXCR4 agonist SDF-1á to permeabilized primary CD4+ T cells pretreated with either DMSO or 100 nM of the CB2 agonist JWH-133 (A) in a representative donor and (B) in multiple donors (mean±SEM; n = 4 donors; **p = 0.0034, *p<0.02). (C–D) GTPãS binding following addition of the CB2 agonist JWH-133 to permeabilized CD4+ T cells pretreated with either DMSO or 100 nM of the CXCR4 agonist SDF-1á (C) in a representative donor and (D) in multiple donors (mean±SEM; n = 4 donors).