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. 2012 Mar 20;7(3):e33893. doi: 10.1371/journal.pone.0033893

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Hegde et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Upregulated genes correlate in their expression and a similar trend is observed for downregulated genes. However, there is inverse correlation in expression between up and downregulated genes.