Table 1. Summary of lesions observed and their characteristics.a .
Treatment | Day post infection | Average # of lesions per section | Lesion size range |
CpG | 1 | 0.3 | 4 to 10 alveoli |
CpG | 2 | 0.8 | 2 to 18 alveoli |
CpG | 3 | 4.3 | 2 to 20 alveoli |
CpG | 6 | 0.3 | 0 to 1 alveolus |
CpG | 13 | 0.0 | No lesions seen |
CpG | 15 | 1.0 | 0 to 2 alveoli |
CpG | 25 | 1.0 | 1 to 2 alveoli |
Control | 1 | 1.1 | 5 to 25 alveoli |
Control | 2 | 12.5 | 2 to 30 alveoli |
Control | 3 | 3.8 | 1 to 40 alveoli |
Control | 6 | 2.00 | 1 to 40 alveoli |
Lung samples from two animals from each group and time point were examined after routine H&E staining. Lesion count is estimated as the average number of lesions per lung section for the two animals. Lesion size is reported as the number of alveoli filled by neutrophils.