Table 2.
Normotensive individuals
| TT (n = 109) |
CT (n = 34) |
CC (n = 4) |
P value genotype |
|
|---|---|---|---|---|
| SBP (mmHg) | ||||
| High salt | 110.5 ± 12.3* | 115.1 ± 12.2 | 118.8 ± 23.7 | 0.03 |
| Low salt | 106.6 ± 12.2 | 113.1 ± 12.8 | 113.3 ± 9.0 | 0.009 |
| DBP (mmHg) | ||||
| High salt | 66.2 ± 8.7* | 67.5 ± 11.0 | 68.0 ± 1.2 | 0.45 |
| Low salt | 63.7 ± 7.9 | 66.3 ± 8.7 | 64.8 ± 8.0 | 0.16 |
| MAP (mmHg) | ||||
| High salt | 81.7 ± 9.4* | 85.7 ± 12.3 | 84.9 ± 10.0 | 0.06 |
| Low salt | 77.7 ± 8.6 | 83.7 ± 10.4 | 85.3 ± 2.8 | 0.001 |
| Heart rate (beats/min) | ||||
| High salt | 58.9 ± 8.4* | 60.5 ± 11.9 | 56.0 ± 5.3 | 0.74 |
| Low salt | 60.7 ± 8.7 | 61.2 ± 10.7 | 61.8 ± 7.3 | 0.73 |
| 24-h sodium (mmol/day) | ||||
| High salt | 240.2 ± 77.9* | 242.2 ± 77.9* | 246.6 ± 118.9* | 0.87 |
| Low salt | 10.1 ± 8.1 | 8.5 ± 7.7 | 12.2 ± 10.2 | 0.60 |
| 24-h potassium (mmol/day) | ||||
| High salt | 77.0 ± 28.2 | 69.4 ± 24.5 | 51.7 ± 27.4 | 0.06 |
| Low salt | 72.4 ± 21.6 | 75.3 ± 24.4 | 80.6 ± 19.9 | 0.41 |
| Plasma renin activity (ng/min per ml) | ||||
| High salt | 0.40 ± 0.39* | 0.37 ± 0.29* | 0.22 ± 0.11* | 0.55 |
| Low salt | 4.36 ± 4.46 | 4.22 ± 2.90 | 5.10 ± 4.13 | 0.95 |
| Aldosterone (ng/dl) | ||||
| High salt | 4.08 ± 3.22* | 3.83 ± 2.00* | 2.51 ± 0.03* | 0.36 |
| Low salt | 19.24 ± 12.00 | 21.98 ± 12.57 | 19.98 ± 11.81 | 0.54 |
| RPF (ml/min per 1.73m2) | ||||
| High salt | 601.4 ± 141.5* | 573.5 ± 126.8 | 518.5 ± 53.0 | 0.24 |
| Low salt | 552.4 ± 134.2 | 544.3 ± 109.1 | 569.0 ± 106.1 | 0.89 |
MAP, mean arterial pressure; RPF, renal plasma flow.
*
P < 0.05 versus low salt.