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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Feb 24;22(7):2376–2379. doi: 10.1016/j.bmcl.2012.02.055

Table 2.

Data for 9c and 9e against resistant viral strains and metabolic stability

EC50 (nM)a human liver microsomeb rat liver microsomeb
HIV-1RTMDR1 K101E E138K t1/2 min CL mL/min/mg t1/2 min CL mL/min/mg
9c 0.31± 0.10 8.8 ± 3.3 9.0 ± 2.6 35 0.20 122 0.057
9e 0.36 ± 0.10 3.4± 1.05 3.9 ± 0.90 30 0.23 84 0.083
3 0.87 ± 0.33 10.8 ± 3.53 11.3 ± 3.76 47 0.15 139 0.050
2 0.49 ± 0.10 5.7 ± 1.4 5.2 ± 1.6 34 0.20 120 0.057
a

Experiments were performed at least in triplicate and data presented as mean ± SD.

b

Data from at least two experiments and presented as means.