Figure 1.
(A) The change from baseline (%) in ROS generation from mononuclear cells (MNC) when fasting samples (pre) were compared to the samples collected 2 hours after glucose ingestion (post). * the percent (%) change in ROS generation in normal weight women with PCOS was greater than that of normal weight ovulatory controls, P < 0.009. † the % change in ROS generation in obese women with PCOS was greater than that of normal weight ovulatory controls, P < 0.003. (B) Representative EMSA bands from the 4 study groups showing the change in quantity of NFκB in nuclear extracts from MNC when fasting samples (pre) were compared to the samples collected 2 hours after glucose ingestion (post). Densitometric quantitative analysis of intranuclear NFκB protein content in MNC. Compared to normal weight ovulatory controls, the % change in NFκB activation was significantly greater in obese ovulatory controls (*, P<0.03), in normal weight women with PCOS (†, P<0.006), and in obese women with PCOS (‡, P<0.002). Adapted from González et al. [5,9], with permission. Copyright The Endocrine Society, 2006.